Ionic Liquids (ILs) are known to form charge alternating layers when exposed to charged surfaces like the surfaces of many nanoparticles. When coated with protein-avoidant ionic liquids (PAILs) in this way, nanoparticles do not gain protein coronas as might be expected. This radically alters their fate in environmental and biological surroundings. The chemical and structural nature of the coating, and the reason for the protein-avoidant effect has not yet been determined. In this project, tools ranging in size scale from single molecules (quantum chemistry) to hundreds of atoms (ab initio molecular dynamics) to thousands of atoms (classical molecular dynamics) to full coated nanoparticles (coarse grained molecular dynamics) will be used to understand the structure of the coating at every scale in collaboration with Eden Tanner at the University of Mississippi.